Literatur-DB: Vaccination with dendritic cells loaded with tumor apoptotic bodies (Apo-DC) in patients with chronic lymphocytic leukemia: effects of various adjuvants and definition of immune response criteria.
| Titel: | Vaccination with dendritic cells loaded with tumor apoptotic bodies (Apo-DC) in patients with chronic lymphocytic leukemia: effects of various adjuvants and definition of immune response criteria. |
| Kategorien: | Chronische Leukämie |
| BuchID: | 42 |
| Autor: | Verschiedene |
| ISBN-10(13): | KA |
| Publikationsdatum: | 2012 06 |
| Number of pages: | 0 |
| Sprache: | Nicht spezifiziert |
| Preis: | 0.00 |
| Bewertung: |
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| Beschreibung: |
AbstractWe previously demonstrated that autologous dendritic cells that have endocytosed apoptotic bodies of chronic lymphocytic leukemia (CLL) cells (Apo-DC) can stimulate antileukemic T cell responses in vitro. In this phase I study, we vaccinated 15 asymptomatic CLL patients at five time points with Apo-DC administered intradermally either alone (cohort I), or in combination with subcutaneous granulocyte-macrophage-colony-stimulating-factor (GM-CSF) (cohort II) or with GM-CSF and intravenous low-dose cyclophosphamide (cohort III). Artikel-Nr.: 61(6):865-79 | PubMed-ID: 22086161 | DOI: 10.1007/s00262-011-1149-5 | ISBN: |
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