Literatur-DB: Dendritic cell-based immunotherapy in myeloid leukaemia: translating fundamental mechanisms into clinical applications.
| Titel: | Dendritic cell-based immunotherapy in myeloid leukaemia: translating fundamental mechanisms into clinical applications. |
| Kategorien: | Akute Leukämie |
| BuchID: | 99 |
| Autor: | Verschiedene |
| ISBN-10(13): | KA |
| Publikationsdatum: | 2008 12 |
| Number of pages: | 0 |
| Sprache: | Nicht spezifiziert |
| Preis: | 0.00 |
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| Beschreibung: |
AbstractImmunotherapy for leukaemia patients, aiming at the generation of anti-leukaemic T cell responses, could provide a new therapeutic approach to eliminate minimal residual disease (MRD) cells in acute myeloid leukaemia (AML). Leukaemic blasts harbour several ways to escape the immune system including deficient MHC class II expression, low levels of co-stimulatory molecules and suppressive cytokines. Therapeutic vaccination with dendritic cells (DC) is now recognized as an important investigational therapy. Due to their unique antigen presenting capacity, immunosuppressive features of the leukaemic blasts can be circumvented. Artikel-Nr.: (188):319-48 | PubMed-ID: 19031033 | DOI: 10.1007/978-3-540-71029-5_15 | ISBN: |
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