Literatur-DB: Quantitative expression of Toll-like receptor-2, -4, and -9 in dendritic cells generated from blasts of patients with acute myeloid leukemia.
| Titel: | Quantitative expression of Toll-like receptor-2, -4, and -9 in dendritic cells generated from blasts of patients with acute myeloid leukemia. |
| Kategorien: | Akute Leukämie |
| BuchID: | 110 |
| Autor: | Verschiedene |
| ISBN-10(13): | KA |
| Publikationsdatum: | 2008 05 |
| Number of pages: | 0 |
| Sprache: | Nicht spezifiziert |
| Preis: | 0.00 |
| Bewertung: |
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| Beschreibung: |
AbstractBACKGROUND:Dendritic cells (DCs) generated from leukemic blasts constitute a promising tool in immunotherapy for acute myeloid leukemia patients (AML-DCs), because AML-DCs express human leukocyte antigens and costimulatory molecules such as CD40, CD80, and CD86 at a higher level than leukemic blasts. Potentiation of AML-DC vaccine might become feasible by the addition of adjuvants such as lipopolysaccharides (LPS) or CPG-rich oligodeoxyribonucleotides binding to Toll-like receptors (TLR) and inducing a stronger Type 1 T-cell response. Artikel-Nr.: 48(5):861-70 | PubMed-ID: 18208411 | DOI: 10.1111/j.1537-2995.2007.01616.x | ISBN: |
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