Literatur-DB: Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.
 
Titel:      Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.
Kategorien:      Malignes Melanom
BuchID:      29
Autor:      Verschiedene
ISBN-10(13):      KA
Publikationsdatum:      2013 07
Number of pages:      0
Sprache:      Nicht spezifiziert
Preis:      0.00
Bewertung:      0 
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Beschreibung:     

Abstract

BACKGROUND:

Many cancers, including melanoma, exclusively express constitutive proteasomes (cPs) and are unable to express immunoproteasomes (iPs). In contrast, mature DCs used for immunotherapy exclusively express iPs. Since proteasomes generate peptides presented by HLA class I molecules, we hypothesized that mature melanoma antigen-loaded DCs engineered to process antigens through cPs would be superior inducers of antimelanoma immunity in vivo.

Artikel-Nr.: 123(7):3135-45 | PubMed-ID: 23934126 | DOI: 10.1172/JCI67544 | ISBN:


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