Literatur-DB: Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.
| Titel: | Melanoma immunotherapy using mature DCs expressing the constitutive proteasome. |
| Kategorien: | Malignes Melanom |
| BuchID: | 29 |
| Autor: | Verschiedene |
| ISBN-10(13): | KA |
| Publikationsdatum: | 2013 07 |
| Number of pages: | 0 |
| Sprache: | Nicht spezifiziert |
| Preis: | 0.00 |
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| Beschreibung: |
AbstractBACKGROUND:Many cancers, including melanoma, exclusively express constitutive proteasomes (cPs) and are unable to express immunoproteasomes (iPs). In contrast, mature DCs used for immunotherapy exclusively express iPs. Since proteasomes generate peptides presented by HLA class I molecules, we hypothesized that mature melanoma antigen-loaded DCs engineered to process antigens through cPs would be superior inducers of antimelanoma immunity in vivo. Artikel-Nr.: 123(7):3135-45 | PubMed-ID: 23934126 | DOI: 10.1172/JCI67544 | ISBN: |
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